Full title : Neuronal interaural level difference response shifts are level - dependent in the rat 1 auditory cortex 2 3 Running head : ILD responses are level - dependent in rat auditory cortex 4 5

Synaptic mechanisms underlying interaural level difference selectivity in rat auditory cortex 1 2 Running Title : Synaptic mechanisms of cortical ILD selectivity

Synaptic mechanisms underlying interaural level difference selectivity in rat auditory cortex 1 2 Running Title: Synaptic mechanisms of cortical ILD selectivity 3 4 Michael Kyweriga, Whitney Stewart, Carolyn Cahill, and Michael Wehr 5 Institute of Neuroscience; Departments of Biology, Human Physiology, and Psychology, 6 University of Oregon, Eugene, OR. 7 8 Corresponding author 9 Michael Wehr, ...

Neuronal interaural level difference response shifts are level-dependent in the rat auditory cortex.

How does the brain accomplish sound localization with invariance to total sound level? Sensitivity to interaural level differences (ILDs) is first computed at the lateral superior olive (LSO) and is observed at multiple levels of the auditory pathway, including the central nucleus of inferior colliculus (ICC) and auditory cortex. In LSO, this ILD sensitivity is level-dependent, such that ILD re...

Monaural and binaural contributions to interaural-level-difference sensitivity in human auditory cortex

Whole-brain functional magnetic resonance imaging was used to measure blood-oxygenation-level-dependent (BOLD) responses in human auditory cortex (AC) to sounds with intensity varying independently in the left and right ears. Echoplanar images were acquired at 3 Tesla with sparse image acquisition once per 12-second block of sound stimulation. Combinations of binaural intensity and stimulus pre...

Michael Kyweriga , Whitney Stewart and Michael Wehr level - dependent in the rat auditory cortex Neuronal interaural level

Synaptic mechanisms underlying interaural level difference selectivity in rat auditory cortex.

The interaural level difference (ILD) is a sound localization cue that is extensively processed in the auditory brain stem and midbrain and is also represented in the auditory cortex. Here, we asked whether neurons in the auditory cortex passively inherit their ILD tuning from subcortical sources or whether their spiking preferences were actively shaped by local inhibition. If inherited, the IL...